Powerful Pain Killer High Purity Lidocaine HCl (CAS: 73-78-9)
|FOB Unit Price:||US $1 US $0.87|
|Purchase Qty. (gram)||FOB Unit Price|
|Transport Package:||Discreet Package|
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- Model NO.: 73-78-9
- Customized: Non-Customized
- Suitable for: Adult
- Purity: >99%
- Specification: ISOO9001
- Powder: Yes
- Certification: ISO 9001, BP
- State: Solid
- Trademark: Yuancheng
- Origin: Hubei, China
|Product Name:||Lidocaine HCL|
|Product Categories:||API;Intermediates & Fine Chemicals;Pharmaceuticals;Amines;Aromatics;Research Chemical;Pharma materials|
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Hemodynamics: Excessive blood levels may cause changes in cardiac output, total peripheral resistance, and mean arterial pressure. With central neural blockade these changes may be attributable to block of autonomic fibers, a direct depressant effect of the local anesthetic agent on various components of the cardiovascular system and/or the beta-adrenergic receptor stimulating action of epinephrine when present. The net effect is normally a modest hypotension when the recommended dosages are not exceeded.
Lidocaine is metabolized rapidly by the liver, and metabolites and unchanged drug are excreted by the kidneys. Biotransformation includes oxidative N-dealkylation, ring hydroxylation, cleavage of the amide linkage, and conjugation. N-dealkylation, a major pathway of biotransformation, yields the metabolites monoethylglycinexylidide and glycinexylidide. The pharmacological/toxicological actions of these metabolites are similar to, but less potent than, those of Lidocaine. Approximately 90% of Lidocaine administered is excreted in the form of various metabolites, and less than 10% is excreted unchanged. The primary metabolite in urine is a conjugate of 4-hydroxy-2, 6-dimethylaniline.
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