Anesthetic Agents Dibucaine HCl With USP30 / EP6 / JP14 Standard CAS:61-12-1 MF:C20H30ClN3O2 MW:379.92 EINECS:200-498-1 Appearance:white powder Purity:99.6%
Description: Dibucaine hydrochloride is a local anesthetic of the amide type now generally used for surface anesthesia. It is one of the most potent and toxic of the long-acting local anesthetics and its parenteral use is restricted. The drug blocks both the initiation and conduction of nerve impulses by decreasing the neuronal membrane's permeability to sodium ions. This reversibly stabilizes the membrane and inhibits depolarization, resulting in the failure of a propagated action potential and subsequent conduction blockade. In combination sodium dibucaine hydrochloride is administered to dogs to induce rapid, humane, painless euthanasia. The euthanasia solution is toxic to wildlife. Euthanized animals must be properly disposed of by deep burial, incineration or other method in compliance with state and local laws
Applications: Spinal anesthesia (high, low, saddle block) and topically to produce surface anesthesia. Eye: To anesthetize conjunctiva and cornea prior to superficial procedures (including tonometry, gonioscopy, removal of foreign bodies or sutures, corneal scraping). Nose and Throat: To abolish laryngeal and esophageal reflexes prior to bronchoscopy, esophagoscopy. Skin: To relieve pruritus, pain, burning.
The COA of Dibucaine HCl:
Items of analysis
White or off-white crystalline powder
By HPLC,to match with the working standard
Ereely soluble in water,in alcohol,in acetone in ahlororm